Nevins walked a pair of batters and hit one in the first six frames of the game, but no Syracuse batter was able to get a hit until the seventh inning as Caira drove a pitch to the wall in right to spoil the no-hitter for Nevins.
Syracuse, who entered the series batting .301 as a team entering the game, was completely overmatched by the USF lefty as she went the distance to earn her team-leading ninth win of the year collecting 11 strikeouts and walking just two in the one-hit bid.
The Bulls held the Orange, a team averaging six runs per game entering the week, to just four runs in the three-game series, while outscoring Syracuse 14-4 in the set.
USF got the benefit of some sloppy play early on as they jumped out to an early 4-0 lead on five first-inning errors by the Orange.
Gina Kafalas paced the Bulls offensively going 2-for-3 from the dish with a run-scored in the error-filled first inning.
The story of the first inning was Syracuse's plague of errors, as the Orange broke their single-game error total in the first inning alone. Five first-inning errors by the Orange gave the Bulls a similar first inning to Saturday's sweep.
For the third consecutive game, USF scored in the opening frame and improved to 17-2 on the year when striking first and 15-4 when they score in the first inning.
Both offenses went quiet after the first as both pitchers settled into a groove and the two teams held each other scoreless the remainder of the game
Nevins' complete game had the audience on edge until the no-hitter was spoiled with a Syracuse double to right field in the seventh, but the freshman finished it out to earn her second win of the weekend and the ninth of the season.
The Bulls will play a midweek double-header against Bethune-Cookman on Wednesday before welcoming in Georgetown for a three-game set over the weekend.