LOUISVILLE - Strong Louisville pitching and a big fourth inning sent the 17th-ranked University of South Florida Bulls to just their third Big East loss of the season.

Ranked 11th in the NFCA, the Cardinals (40-2 overall, 11-2 Big East) broke free to score five runs in the fourth and four more in the fifth, ending the game early to beat the Bulls (40-8, 13-3) in Louisville, Ky. Wednesday.

Reigning Big East Player of the Week Alicja Wolny drove an RBI double off the bottom of the wall in right to get Louisville on the board in the fourth.

Two batters later, Jordan Trimble took a high pitch over the fence in right, clearing the bases for her first career grand slam, and chasing Nevins from the game. Nevins had thrown three perfect innings to start the game before running into trouble.

Louisville put up four more in the fifth, the big blow coming on a three-run homer off the bat of Taner Fowler as the Cardinals walked off with the win.

USF stranded seven runners on base, including three in the second and two in scoring position in the fourth as the Louisville pitchers did a great job of mixing speeds in key situations against the Bulls.

Kourtney Salvarola had another strong game at the plate, going 2-2 to finish with four hits Wednesday. Ashli Goff and Jessica Mouse would record the only other hits for USF.